- claim_text
GABAergic SNr projection neurons fire spontaneous high-frequency tonic spikes sustained by Na+-dependent TRPC3, persistent Na+ and Kv3-like K+ currents, with afferent striatal/pallidal GABAergic and STN glutamatergic inputs sculpting their output.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuroscience.2011.07.061",
"claim": "GABAergic SNr projection neurons fire spontaneous high-frequency tonic spikes sustained by Na+-dependent TRPC3, persistent Na+ and Kv3-like K+ currents, with afferent striatal/pallidal GABAergic and STN glutamatergic inputs sculpting their output.",
"cite_key": "Zhou2011",
"evidence": "Review of intrinsic biophysical mechanisms and afferent integration in SNr GABAergic projection neurons.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "rodent (review of slice and in vivo electrophysiology)",
"source_cluster_id": "cluster_02",
"replication_status": "replicated",
"claim_source_sentence": "Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons.",
"replication_evidence_dois": [
"10.7554/elife.55592",
"10.1371/journal.pcbi.1006782"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-0e062144e62e"
]
- source_span
Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons.
- evidence_refs
[
{
"ref": "paper:paper-0e062144e62e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}