Version history

{
  "scope": "mouse (6-OHDA depletion + electrophysiology)",
  "claim_text": "Chronic dopamine depletion in mouse selectively weakens direct-pathway GABAergic control of SNr neurons by altering decay kinetics of GABA synaptic currents while leaving indirect-pathway GPe→SNr signaling intact, inverting the balance of inhibitory drive over basal ganglia output.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.nbd.2024.106512",
    "claim": "Chronic dopamine depletion in mouse selectively weakens direct-pathway GABAergic control of SNr neurons by altering decay kinetics of GABA synaptic currents while leaving indirect-pathway GPe→SNr signaling intact, inverting the balance of inhibitory drive over basal ganglia output.",
    "cite_key": "Aristieta2024",
    "evidence": "In vivo plus slice patch-clamp recordings of SNr neurons in dopamine-depleted vs control mice.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse (6-OHDA depletion + electrophysiology)",
    "source_cluster_id": "cluster_02",
    "replication_status": "replicated",
    "claim_source_sentence": "Using a combination of in vivo and slice electrophysiology, we find that dopamine depletion selectively weakens the direct pathway's influence over neural activity in the SNr due to changes in the decay kinetics of GABA-mediated synaptic currents.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.0434-18.2018",
      "10.7554/elife.55592"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-d55ebc38aa73"
  ],
  "source_span": "Using a combination of in vivo and slice electrophysiology, we find that dopamine depletion selectively weakens the direct pathway's influence over neural activity in the SNr due to changes in the decay kinetics of GABA-mediated synaptic currents.",
  "study_system": "mouse (6-OHDA depletion + electrophysiology)",
  "evidence_refs": [
    {
      "ref": "paper:paper-d55ebc38aa73"
    }
  ],
  "section_title": "Classical Anatomy of the Triple Descending Projection",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "In vivo plus slice patch-clamp recordings of SNr neurons in dopamine-depleted vs control mice.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}