- raw_fields
{
"n": 20,
"doi": "10.1371/journal.pbio.3003549",
"claim": "Human fast-spiking PV interneurons have lower AP firing threshold due to deficiency in Kv1.1 and Kv1.2 channels at the AIS compared to mouse neurons, with moderately elongated AIS",
"evidence": "Human fast-spiking PV interneurons have lower AP firing threshold due to deficiency in Kv1.1 and Kv1.2 channels at the AIS compared to mouse neurons, with moderately elongated AIS",
"effect_size": "Lower AP firing threshold in human vs mouse PV neurons, Kv1.1/Kv1.2 deficiency at AIS",
"text_access": "fulltext",
"study_system": "human neocortex surgical tissue vs mouse neocortex",
"replication_status": "replication_unknown",
"claim_source_sentence": "The action potential (AP) firing threshold was lower in human neurons than in mouse neurons. This was due to a deficiency in low-voltage-activated inhibitory Kv1.1 and Kv1.2 potassium channels in the axon initial segment (AIS), a specialized axonal region that determines AP threshold and initiation, in human cells.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "The action potential (AP) firing threshold was lower in human neurons than in mouse neurons."
}- source_refs
[
"paper:paper-7f008ed47247"
]
- source_span
The action potential (AP) firing threshold was lower in human neurons than in mouse neurons. This was due to a deficiency in low-voltage-activated inhibitory Kv1.1 and Kv1.2 potassium channels in the axon initial segment (AIS), a specialized axonal region that determines AP threshold and initiation, in human cells.
- evidence_refs
[
{
"ref": "paper:paper-7f008ed47247"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}