Details

scope
cortical model of PV-mediated gamma oscillation plasticity
claim_text
Gamma oscillation plasticity is mediated by parvalbumin interneurons, with computational modeling showing how PV–SST/VIP interactions set learning-induced oscillation states.
section_id
section_12
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-12-computational-models
source_kind
review_finding
source_path
evidence/section_12_evidence_package.json
source_span
A microcircuit computational model of CA3 gamma oscillations predicts CP-AMPAR plasticity onto PVIs critically outperforms pyramidal cell plasticity in increasing gamma power and completely accounts for gamma potentiation.
study_system
cortical model of PV-mediated gamma oscillation plasticity
section_title
Computational Models of VIP Circuit Function
evidence_summary
Authors developed a cortical model of PV-mediated gamma oscillation plasticity and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replicated_independent
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-12-computational-models
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "id": "cluster_11_finding_155",
  "doi": "10.1126/sciadv.adj7427",
  "pmid": "38295164",
  "year": "2024",
  "claim": "Gamma oscillation plasticity is mediated by parvalbumin interneurons, with computational modeling showing how PV–SST/VIP interactions set learning-induced oscillation states.",
  "pmcid": "PMC10830109",
  "title": "Gamma oscillation plasticity is mediated via parvalbumin interneurons",
  "authors": "Hadler MD, Tzilivaki A, Schmitz D, Alle H, Geiger JRP.",
  "journal": "Science Advances",
  "cite_key": "Hadler2024",
  "evidence": "Authors developed a cortical model of PV-mediated gamma oscillation plasticity and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
  "vip_role": "oscillations",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "cortical model of PV-mediated gamma oscillation plasticity",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 154,
  "claim_source_sentence": "A microcircuit computational model of CA3 gamma oscillations predicts CP-AMPAR plasticity onto PVIs critically outperforms pyramidal cell plasticity in increasing gamma power and completely accounts for gamma potentiation.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-058858c072a9"
]
evidence_refs
[
  {
    "ref": "paper:paper-058858c072a9"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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