Version history

{
  "scope": "mouse V1 L2/3; PV interneurons and pyramidal neurons; 2P imaging + paired recordings",
  "claim_text": "Excitatory L2/3 PV-cell connections in mouse V1 are functionally tuned despite their dense connectivity — individual PV+ interneurons strongly inhibit nearby pyramidal cells that share their visual tuning and provide them with strong excitation.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2023.12.013",
    "claim": "Excitatory L2/3 PV-cell connections in mouse V1 are functionally tuned despite their dense connectivity — individual PV+ interneurons strongly inhibit nearby pyramidal cells that share their visual tuning and provide them with strong excitation.",
    "cite_key": "Znamenskiy2024",
    "evidence": "Combined 2P calcium imaging and paired recordings of PV-pyramidal connections in mouse V1.",
    "effect_size": "Feature-tuned PV→Pyr inhibition co-tuned with reciprocal excitation despite dense connectivity.",
    "text_access": "abstract_only",
    "study_system": "mouse V1 L2/3; PV interneurons and pyramidal neurons; 2P imaging + paired recordings",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic weights of their connections to nearby pyramidal neurons are specifically tuned according to the similarity of the cells' responses. Individual PV+ cells strongly inhibit those pyramidal cells that provide them with strong excitation and share their visual selectivity.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Feature-tuned PV→Pyr inhibition co-tuned with reciprocal excitation despite dense connectivity.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-7ab8027f125a"
  ],
  "source_span": "By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic weights of their connections to nearby pyramidal neurons are specifically tuned according to the similarity of the cells' responses. Individual PV+ cells strongly inhibit those pyramidal cells that provide them with strong excitation and share thei...",
  "study_system": "mouse V1 L2/3; PV interneurons and pyramidal neurons; 2P imaging + paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-7ab8027f125a"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Combined 2P calcium imaging and paired recordings of PV-pyramidal connections in mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}