- raw_fields
{
"n": 0,
"doi": "10.1523/JNEUROSCI.2538-10.2011",
"claim": "NRG1 promotes excitatory synapse development specifically in GABAergic interneurons, not glutamatergic neurons, and deletion of ErbB4 in PV+ interneurons reduces mEPSC frequency and amplitude.",
"evidence": "",
"effect_size": "ErbB4 deletion in PV+ interneurons reduced mEPSC frequency and amplitude",
"text_access": "abstract_only",
"study_system": "mouse cortical PV interneurons, ErbB4 conditional knockout",
"replication_status": "replication_unknown",
"claim_source_sentence": "NRG1 increased both the number and size of PSD-95 puncta and the frequency and amplitude of miniature EPSCs in GABAergic interneurons. In contrast, NRG1 treatment had no effect on either the number or size of excitatory synapses in glutamatergic neurons.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "deletion of ErbB4 in parvalbumin-positive interneurons led to reduced frequency and amplitude of mEPSCs, providing in vivo evidence that ErbB4 is important in excitatory synaptogenesis in interneurons."
}- source_refs
[
"paper:1e860525-a982-44de-b96e-fd7dce2352cf"
]
- source_span
NRG1 increased both the number and size of PSD-95 puncta and the frequency and amplitude of miniature EPSCs in GABAergic interneurons. In contrast, NRG1 treatment had no effect on either the number or size of excitatory synapses in glutamatergic neurons.
- evidence_refs
[
{
"ref": "paper:1e860525-a982-44de-b96e-fd7dce2352cf"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}