Levodopa enhances reinforcement learning in non-tremor Parkinson's disease pati…

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scope: human PD patients stratified by motor phenotype
claim_text: Levodopa enhances reinforcement learning in non-tremor Parkinson's disease patients but not in tremor-dominant patients, indicating motor phenotype as a critical moderator of dopaminergic cognitive effects.
section_id: section_13
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_13_evidence_package.json
effect_size: Levodopa effect on positive learning rate present in akinetic-rigid but absent in tremor-dominant patients
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-13
source_kind: review_finding
source_path: evidence/section_13_evidence_package.json
source_span: Introduction Parkinson’s disease is clinically defined by bradykinesia, rigidity, and tremor.
study_system: human PD patients stratified by motor phenotype
section_title: Computational Models of Loop Function
evidence_summary: Cohort of PD patients stratified by motor phenotype; on/off levodopa probabilistic selection task.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: contested
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-13
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_13_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 63,
  "doi": "10.1093/brain/awaa335",
  "claim": "Levodopa enhances reinforcement learning in non-tremor Parkinson's disease patients but not in tremor-dominant patients, indicating motor phenotype as a critical moderator of dopaminergic cognitive effects.",
  "cite_key": "VanNuland2020",
  "evidence": "Cohort of PD patients stratified by motor phenotype; on/off levodopa probabilistic selection task.",
  "effect_size": "Levodopa effect on positive learning rate present in akinetic-rigid but absent in tremor-dominant patients",
  "text_access": "fulltext",
  "study_system": "human PD patients stratified by motor phenotype",
  "source_cluster_id": "cluster_12",
  "replication_status": "contested",
  "claim_source_sentence": "Introduction Parkinson’s disease is clinically defined by bradykinesia, rigidity, and tremor.",
  "replication_evidence_dois": [
    "10.1126/science.1102941"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-34e94fd8722c"
]

evidence_refs

[
  {
    "ref": "paper:paper-34e94fd8722c"
  }
]

source_policy

{
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  "notes": [
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  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
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Levodopa enhances reinforcement learning in non-tremor Parkinson's disease pati…

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