Details
- scope
- mouse, hippocampus, AβO injection + optogenetics in vivo
- claim_text
- Optogenetic activation of PV interneurons selectively restores AβO-induced gamma oscillation impairments in vivo
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- selective restoration of gamma by PV activation, theta by SST activation
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- optogenetic activation of channelrhodopsin-2 (ChR2)-expressing SST and PV interneurons in AβO-injected mice selectively restored AβO-induced reduction of the peak power of theta and gamma oscillations, respectively
- study_system
- mouse, hippocampus, AβO injection + optogenetics in vivo
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- SST activation restored theta, PV activation restored gamma; AβO increased initial GABA release probability to depress SST/PV inhibitory input at theta/gamma frequencies respectively
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1007/s00429-020-02044-3", "claim": "Optogenetic activation of PV interneurons selectively restores AβO-induced gamma oscillation impairments in vivo", "evidence": "SST activation restored theta, PV activation restored gamma; AβO increased initial GABA release probability to depress SST/PV inhibitory input at theta/gamma frequencies respectively", "effect_size": "selective restoration of gamma by PV activation, theta by SST activation", "text_access": "fulltext", "study_system": "mouse, hippocampus, AβO injection + optogenetics in vivo", "replication_status": "independently_replicated", "claim_source_sentence": "optogenetic activation of channelrhodopsin-2 (ChR2)-expressing SST and PV interneurons in AβO-injected mice selectively restored AβO-induced reduction of the peak power of theta and gamma oscillations, respectively", "replication_evidence_dois": [ "10.1073/pnas.2400420121" ], "effect_size_source_sentence": "optogenetic activation of ChR2-expressing SST and PV interneurons in AβO-injected mice selectively restored AβO-induced reduction of the peak power of theta and gamma oscillations, respectively" }- source_refs
[ "paper:5e37237e-7c03-4830-9b87-0f50b9e418a1" ]
- evidence_refs
[ { "ref": "paper:5e37237e-7c03-4830-9b87-0f50b9e418a1" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }