Cathodal stimulation activates the hyperdirect pathway at substantially lower c…

Details

scope: rat
claim_text: Cathodal stimulation activates the hyperdirect pathway at substantially lower current thresholds (2.46 ± 0.8 mA) than anodal stimulation (5.26 ± 1.4 mA) in patient-specific subthalamic models.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size: 2.46 ± 0.8 mA
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: On average, the cathodic current threshold for HDP activation was 2.46 ± 0.8 mA compared with 5.26 ± 1.4 mA for anodic stimulation ( P = 0.031).
study_system: rat
section_title: Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary: Neural pathway activation in the subthalamic region depends on stimulation polarity.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1093/braincomms/fcaf006",
  "claim": "Cathodal stimulation activates the hyperdirect pathway at substantially lower current thresholds (2.46 ± 0.8 mA) than anodal stimulation (5.26 ± 1.4 mA) in patient-specific subthalamic models.",
  "cite_key": "Borgheai2024",
  "evidence": "Neural pathway activation in the subthalamic region depends on stimulation polarity.",
  "effect_size": "2.46 ± 0.8 mA",
  "text_access": "fulltext",
  "study_system": "rat",
  "source_cluster_id": "cluster_04",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "On average, the cathodic current threshold for HDP activation was 2.46 ± 0.8 mA compared with 5.26 ± 1.4 mA for anodic stimulation ( P = 0.031).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "On average, the cathodic current threshold for HDP activation was 2.46 ± 0.8 mA compared with 5.26 ± 1.4 mA for anodic stimulation ( P = 0.031)."
}

source_refs

[
  "paper:paper-009026a190b2"
]

evidence_refs

[
  {
    "ref": "paper:paper-009026a190b2"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

Cathodal stimulation activates the hyperdirect pathway at substantially lower c…

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Replication

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