Version history

{
  "scope": "human and mouse L1 cortex; Patch-seq + cross-species transcriptomic alignment",
  "claim_text": "Jorstad et al. (2023) identified human-specific L1 interneuron transcriptomic types (e.g., VIP PCDH20 and SST BAGE2) that are homologous to deeper mouse t-types but exhibit no morphologically equivalent neurons in mouse L1, indicating type-specific divergence across species.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.adf0805",
    "claim": "Jorstad et al. (2023) identified human-specific L1 interneuron transcriptomic types (e.g., VIP PCDH20 and SST BAGE2) that are homologous to deeper mouse t-types but exhibit no morphologically equivalent neurons in mouse L1, indicating type-specific divergence across species.",
    "title": null,
    "cite_key": "Chartrand2023",
    "evidence": "Cross-species Patch-seq comparison of L1 cortical interneurons; human VIP PCDH20 and SST BAGE2 t-types absent from mouse L1; L1 VIP TSPAN12 cells share descending axon collaterals + stellate dendrites + high sag conserved across species.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "human and mouse L1 cortex; Patch-seq + cross-species transcriptomic alignment",
    "target_section": "section_02",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 18,
    "claim_source_sentence": "No mouse L1 neurons had morphologies resembling the unmatched human L1 t-types (VIP PCDH20 and SST BAGE12, homologous to deeper mouse t-types), and the MC4R subclass was less morphologically distinct, providing evidence for type-specific divergence across species."
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-86dac47be132"
  ],
  "source_span": "No mouse L1 neurons had morphologies resembling the unmatched human L1 t-types (VIP PCDH20 and SST BAGE12, homologous to deeper mouse t-types), and the MC4R subclass was less morphologically distinct, providing evidence for type-specific divergence across species.",
  "study_system": "human and mouse L1 cortex; Patch-seq + cross-species transcriptomic alignment",
  "evidence_refs": [
    {
      "ref": "paper:paper-86dac47be132"
    }
  ],
  "section_title": "Introduction",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cross-species Patch-seq comparison of L1 cortical interneurons; human VIP PCDH20 and SST BAGE2 t-types absent from mouse L1; L1 VIP TSPAN12 cells share descending axon collaterals + stellate dendrites + high sag conserved across species.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}