Version history

{
  "scope": "mouse neocortex, PVcre+; TrkB F/F conditional knockout",
  "claim_text": "Conditional ablation of TrkB receptor in PV cells leads to significant downregulation of PV neuron number, profoundly reduced inhibitory synaptic connections between basket cells and pyramidal neurons, and reduced gamma oscillations",
  "raw_fields": {
    "n": 8,
    "doi": "10.1093/cercor/bhx173",
    "claim": "Conditional ablation of TrkB receptor in PV cells leads to significant downregulation of PV neuron number, profoundly reduced inhibitory synaptic connections between basket cells and pyramidal neurons, and reduced gamma oscillations",
    "evidence": "Conditional ablation of TrkB receptor in PV cells leads to significant downregulation of PV neuron number, profoundly reduced inhibitory synaptic connections between basket cells and pyramidal neurons, and reduced gamma oscillations",
    "effect_size": "Significant downregulation of PV neuron number; profoundly reduced BC-PN synaptic connections",
    "text_access": "fulltext",
    "study_system": "mouse neocortex, PVcre+; TrkB F/F conditional knockout",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "There was a significant downregulation in parvalbumin neuron number in cerebral and cerebellar cortices of TrkB cKO mice. In addition, inhibitory synaptic connections between basket cells and pyramidal neurons were profoundly reduced in the neocortex of TrkB cKO mice.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "There was a significant downregulation in parvalbumin neuron number in cerebral and cerebellar cortices of TrkB cKO mice."
  },
  "section_id": "section_04_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json",
  "effect_size": "Significant downregulation of PV neuron number; profoundly reduced BC-PN synaptic connections",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-0e6901ecce80"
  ],
  "source_span": "There was a significant downregulation in parvalbumin neuron number in cerebral and cerebellar cortices of TrkB cKO mice. In addition, inhibitory synaptic connections between basket cells and pyramidal neurons were profoundly reduced in the neocortex of TrkB cKO mice.",
  "study_system": "mouse neocortex, PVcre+; TrkB F/F conditional knockout",
  "evidence_refs": [
    {
      "ref": "paper:paper-0e6901ecce80"
    }
  ],
  "section_title": "Morphological Diversity: Basket Cells, Chandelier Cells, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Conditional ablation of TrkB receptor in PV cells leads to significant downregulation of PV neuron number, profoundly reduced inhibitory synaptic connections between basket cells and pyramidal neurons, and reduced gamma oscillations",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}