Details
- scope
- CA1 oriens-alveus interneurons, hippocampal slices, dynamic clamp (50 kHz)
- claim_text
- Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons
- section_id
- section_12_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- effect_size
- nonmonotonic relationship between AP frequency and Kv3 deactivation rate with maximum slightly above original value
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- In conclusion, Kv3 channels are necessary for the FS phenotype of OA interneurons, and several of their gating properties appear to be optimized for high-frequency repetitive activity.
- study_system
- CA1 oriens-alveus interneurons, hippocampal slices, dynamic clamp (50 kHz)
- section_title
- Computational Models of PV Circuit Function
- evidence_summary
- Dynamic clamp experiments adding/subtracting artificial Kv3 conductance in hippocampal OA interneurons
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.23-06-02058.2003", "claim": "Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons", "evidence": "Dynamic clamp experiments adding/subtracting artificial Kv3 conductance in hippocampal OA interneurons", "effect_size": "nonmonotonic relationship between AP frequency and Kv3 deactivation rate with maximum slightly above original value", "text_access": "abstract_only", "study_system": "CA1 oriens-alveus interneurons, hippocampal slices, dynamic clamp (50 kHz)", "replication_status": "replication_unknown", "claim_source_sentence": "In conclusion, Kv3 channels are necessary for the FS phenotype of OA interneurons, and several of their gating properties appear to be optimized for high-frequency repetitive activity.", "replication_evidence_dois": [], "effect_size_source_sentence": "Application of artificial Kv3 conductance with altered deactivation kinetics revealed a nonmonotonic relationship between mean AP frequency and deactivation rate, with a maximum slightly above the original value." }- source_refs
[ "paper:paper-28b3df6a6c8c" ]
- evidence_refs
[ { "ref": "paper:paper-28b3df6a6c8c" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }