Interferon-γ augments GABA release in the developing neocortex via nitric oxide…

Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity — Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to enhance inhibitory transmission

{
  "n": 5,
  "doi": "10.3389/fncel.2022.913299",
  "claim": "Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity — Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to enhance inhibitory transmission",
  "title": null,
  "cite_key": "Dohne2022",
  "evidence": "Reported in Frontiers in cellular neuroscience (2022); from Body of abstract.",
  "effect_size": "5",
  "text_access": "abstract_only",
  "study_system": "rat",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 312,
  "claim_source_sentence": "Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to enhance inhibitory transmission.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Here, we investigated the acute effects of IFN-γ on γ-amino-butyric acid (GABA)ergic currents in layer 5 pyramidal neurons of the somatosensory cortex of rats at the end of the first postnatal week, a period of GABA-dependent cortical maturation."
}

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