Version history

{
  "scope": "mouse cortex developmental L6 CT connectivity",
  "claim_text": "L6 corticothalamic axons in mouse cortex extend in phases—first elongating within L6 and later branching translaminarly into L4—and form functional AMPA-receptor-containing synapses preferentially onto PV interneurons rather than the more numerous excitatory neurons of L6 and L4.",
  "raw_fields": {
    "n": "developmental mouse cortex; sample size in figures",
    "doi": "10.1016/j.celrep.2025.116792",
    "claim": "L6 corticothalamic axons in mouse cortex extend in phases—first elongating within L6 and later branching translaminarly into L4—and form functional AMPA-receptor-containing synapses preferentially onto PV interneurons rather than the more numerous excitatory neurons of L6 and L4.",
    "cite_key": "GutmanWei2026",
    "evidence": "Developmental tracing of L6 CT axons in mouse cortex, paired recordings, and AMPA-receptor minimal-stimulation assays of cell-type-biased synaptogenesis.",
    "effect_size": "L6 CT synapses preferentially onto PV; rare onto excitatory cells; functional AMPA from outset, no detectable silent synapses",
    "text_access": "fulltext",
    "study_system": "mouse cortex developmental L6 CT connectivity",
    "argument_role": "supporting",
    "replication_status": "consistent with L6 CT functional output to L5a > L4 excitatory cells (Crandall 2014)",
    "claim_source_sentence": "Layer 6 corticothalamic neurons (L6CThNs) provide a striking example of preferential synaptic connectivity. In both L4 and L6, the intracortical axons of L6CThNs form frequent synaptic connections onto parvalbumin-positive (PV) inhibitory interneurons. In contrast, L6CThNs rarely synapse onto excitatory neurons, even though excitatory neurons far outnumber PV interneurons in both cortical layers.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.1325-14.2014"
    ],
    "effect_size_source_sentence": "L6CThNs form functional AMPA-receptor-containing synapses preferentially onto PV interneurons. Silent L6CThN synapses are not detected."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L6 CT synapses preferentially onto PV; rare onto excitatory cells; functional AMPA from outset, no detectable silent synapses",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-d8c260dd6b59"
  ],
  "source_span": "Layer 6 corticothalamic neurons (L6CThNs) provide a striking example of preferential synaptic connectivity. In both L4 and L6, the intracortical axons of L6CThNs form frequent synaptic connections onto parvalbumin-positive (PV) inhibitory interneurons. In contrast, L6CThNs rarely synapse onto excitatory neurons, even though excitatory neurons far outnumber PV interneurons in both cortical layers.",
  "study_system": "mouse cortex developmental L6 CT connectivity",
  "evidence_refs": [
    {
      "ref": "paper:paper-d8c260dd6b59"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Developmental tracing of L6 CT axons in mouse cortex, paired recordings, and AMPA-receptor minimal-stimulation assays of cell-type-biased synaptogenesis.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with L6 CT functional output to L5a > L4 excitatory cells (Crandall 2014)",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}