VIP-expressing interneurons, like PV interneurons, are also impaired in Scn1a+/…

Details

scope: mouse Scn1a+/- Dravet model, VIP and PV interneurons
claim_text: VIP-expressing interneurons, like PV interneurons, are also impaired in Scn1a+/- Dravet syndrome mice, suggesting that Nav1.1 dysfunction affects multiple interneuron populations beyond the canonical fast-spiking PV cells.
section_id: section_05_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
effect_size: VIP interneurons impaired in addition to PV interneurons in Scn1a+/- mice
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-05
source_kind: review_finding
source_path: evidence/section_05_evidence_package.json
source_span: Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.
study_system: mouse Scn1a+/- Dravet model, VIP and PV interneurons
section_title: Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
evidence_summary: Electrophysiological characterization of VIP interneurons in Dravet mice showing impaired firing alongside PV dysfunction.
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-05
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.7554/elife.46846",
  "claim": "VIP-expressing interneurons, like PV interneurons, are also impaired in Scn1a+/- Dravet syndrome mice, suggesting that Nav1.1 dysfunction affects multiple interneuron populations beyond the canonical fast-spiking PV cells.",
  "evidence": "Electrophysiological characterization of VIP interneurons in Dravet mice showing impaired firing alongside PV dysfunction.",
  "effect_size": "VIP interneurons impaired in addition to PV interneurons in Scn1a+/- mice",
  "text_access": "abstract_only",
  "study_system": "mouse Scn1a+/- Dravet model, VIP and PV interneurons",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome."
}

source_refs

[
  "paper:paper-038d4952015c"
]

evidence_refs

[
  {
    "ref": "paper:paper-038d4952015c"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

VIP-expressing interneurons, like PV interneurons, are also impaired in Scn1a+/…

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