Version history

{
  "scope": "Mouse V1, awake, in vivo extracellular recordings; VGAT-ChR2 transgenic line; 4 animals",
  "claim_text": "Mouse V1, S1, and motor cortex operate as inhibition-stabilized networks during spontaneous activity, evidenced by paradoxical suppression of inhibitory cells upon optogenetic activation of inhibitory neurons.",
  "raw_fields": {
    "n": 6,
    "doi": "10.7554/elife.54875",
    "claim": "Mouse V1, S1, and motor cortex operate as inhibition-stabilized networks during spontaneous activity, evidenced by paradoxical suppression of inhibitory cells upon optogenetic activation of inhibitory neurons.",
    "cite_key": "Sanzeni2020",
    "evidence": "Optogenetic stimulation of all inhibitory cells (VGAT-ChR2 line) during spontaneous activity in dark produced paradoxical decrease of inhibitory firing rate, consistent with strong recurrent E→E coupling stabilized by inhibition.",
    "effect_size": "median initial slope −6.9 ± 3.5 spk/s (paradoxical suppression); 6/6 inhibitory units showed initial negative slope",
    "text_access": "fulltext",
    "study_system": "Mouse V1, awake, in vivo extracellular recordings; VGAT-ChR2 transgenic line; 4 animals",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Together, these results support the idea that the cortex operates in the ISN regime across a range of areas and brain states.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.7554/eLife.49967",
      "10.1038/nature11526"
    ],
    "effect_size_source_sentence": "Confirming that expectation, in one experimental session we measured inhibitory responses to stimulation while animals were in the dark (with the blue optogenetic light shielded with light-blocking materials), and found paradoxical suppression (N = 6/6 inhibitory units with initial negative slope, median initial slope −6.9 ± 3.5 spk/s; p = 0.046, median < 0, Mann-Whitney U test)."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "median initial slope −6.9 ± 3.5 spk/s (paradoxical suppression); 6/6 inhibitory units showed initial negative slope",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-d6edd2b57842"
  ],
  "source_span": "Together, these results support the idea that the cortex operates in the ISN regime across a range of areas and brain states.",
  "study_system": "Mouse V1, awake, in vivo extracellular recordings; VGAT-ChR2 transgenic line; 4 animals",
  "evidence_refs": [
    {
      "ref": "paper:paper-d6edd2b57842"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic stimulation of all inhibitory cells (VGAT-ChR2 line) during spontaneous activity in dark produced paradoxical decrease of inhibitory firing rate, consistent with strong recurrent E→E coupling stabilized by inhibition.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}