Details

scope
vip-interneurons
claim_text
VIP interneurons produce localized, lateral disinhibition opening 'holes' in the SST-mediated blanket of inhibition rather than uniform disinhibition.
section_id
section_09
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_09_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-09-cross-areas
source_kind
review_finding
source_path
evidence/section_09_evidence_package.json
section_title
VIP Interneurons Across Brain Regions
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
unevaluated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-09-cross-areas
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_09_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
raw_fields
{
  "n": null,
  "doi": "10.1523/jneurosci.3646-15.2016",
  "year": "2016",
  "claim": "VIP interneurons produce localized, lateral disinhibition opening 'holes' in the SST-mediated blanket of inhibition rather than uniform disinhibition.",
  "title": null,
  "region": "V1",
  "cite_key": "Karnani2016b",
  "effect_size": null,
  "text_access": "abstract_only",
  "conflict_flag": false,
  "fig_table_ref": null,
  "_source_cluster": "cluster_08_brain_regions",
  "evidence_gap_flag": false,
  "unreplicated_flag": false,
  "replication_status": null,
  "_source_cluster_index": 3,
  "claim_source_sentence": "Inhibitory interneurons in the neocortex often connect in a promiscuous and extensive fashion, extending a \"blanket of inhibition\" on the circuit. This raises the problem of how can excitatory activity propagate in the midst of this widespread inhibition. One solution to this problem could be the vasoactive intestinal peptide (VIP) interneurons, which disinhibit other interneurons. To explore how "
}
source_refs
[
  "paper:paper-0a3cf7627c63"
]
source_span
Inhibitory interneurons in the neocortex often connect in a promiscuous and extensive fashion, extending a "blanket of inhibition" on the circuit. This raises the problem of how can excitatory activity propagate in the midst of this widespread inhibition. One solution to this problem could be the vasoactive intestinal peptide (VIP) interneurons, which disinhibit other interneurons. To explore how
evidence_refs
[
  {
    "ref": "paper:paper-0a3cf7627c63"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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