Details
- scope
- mouse, toxic and genetic demyelination models
- claim_text
- Loss of PV+ axon myelin reduces presynaptic terminals, increases synaptic failures, and abolishes optogenetically driven gamma oscillations in vivo; selectively theta rhythms are amplified with interictal epileptic discharges
- section_id
- section_10_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- effect_size
- Theta rhythms amplified and accompanied by highly synchronized interictal epileptic discharges during quiet wakefulness
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-10
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- Loss of compact myelin reduces PV+ interneuron presynaptic terminals and increases failures, and the weak phasic inhibition of pyramidal neurons abolishes optogenetically driven gamma oscillations in vivo.
- study_system
- mouse, toxic and genetic demyelination models
- section_title
- Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
- evidence_summary
- Loss of PV+ axon myelin reduces presynaptic terminals, increases synaptic failures, and abolishes optogenetically driven gamma oscillations in vivo; selectively theta rhythms are amplified with interictal epileptic discharges
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-10
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.7554/eLife.73827", "claim": "Loss of PV+ axon myelin reduces presynaptic terminals, increases synaptic failures, and abolishes optogenetically driven gamma oscillations in vivo; selectively theta rhythms are amplified with interictal epileptic discharges", "evidence": "Loss of PV+ axon myelin reduces presynaptic terminals, increases synaptic failures, and abolishes optogenetically driven gamma oscillations in vivo; selectively theta rhythms are amplified with interictal epileptic discharges", "effect_size": "Theta rhythms amplified and accompanied by highly synchronized interictal epileptic discharges during quiet wakefulness", "text_access": "fulltext", "study_system": "mouse, toxic and genetic demyelination models", "replication_status": "replication_unknown", "claim_source_sentence": "Loss of compact myelin reduces PV+ interneuron presynaptic terminals and increases failures, and the weak phasic inhibition of pyramidal neurons abolishes optogenetically driven gamma oscillations in vivo.", "replication_evidence_dois": [], "effect_size_source_sentence": "Strikingly, during behaviors of quiet wakefulness selectively theta rhythms are amplified and accompanied by highly synchronized interictal epileptic discharges." }- source_refs
[ "paper:paper-6a1d4be46c47" ]
- evidence_refs
[ { "ref": "paper:paper-6a1d4be46c47" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }