Details

scope
Adult mouse striatum, basal ganglia, cortex, hippocampus etc., Drop-seq scRNA-seq
section_id
section_11
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
effect_size
690
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-11
source_kind
review_finding
source_path
evidence/section_11_evidence_package.json
source_span
To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile RNA expression in 690,000 individual cells, sampled from nine regions of the adult mouse brain.
study_system
Adult mouse striatum, basal ganglia, cortex, hippocampus etc., Drop-seq scRNA-seq
section_title
Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
evidence_summary
Computational classification of 565 cell populations; markers for the rare striatal SPN population identified.
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-11
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
claim_text
Drop-seq single-cell profiling of 690,000 cells across nine adult mouse brain regions identifies 565 transcriptionally distinct cell populations and reveals a rare spiny projection neuron population in striatum beyond the canonical D1/D2 dichotomy.
raw_fields
{
  "n": 690000,
  "doi": "10.1016/j.cell.2018.07.028",
  "claim": "Drop-seq single-cell profiling of 690,000 cells across nine adult mouse brain regions identifies 565 transcriptionally distinct cell populations and reveals a rare spiny projection neuron population in striatum beyond the canonical D1/D2 dichotomy.",
  "cite_key": "Saunders2018a",
  "evidence": "Computational classification of 565 cell populations; markers for the rare striatal SPN population identified.",
  "effect_size": "690",
  "text_access": "fulltext",
  "study_system": "Adult mouse striatum, basal ganglia, cortex, hippocampus etc., Drop-seq scRNA-seq",
  "source_cluster_id": "cluster_10",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile RNA expression in 690,000 individual cells, sampled from nine regions of the adult mouse brain.",
  "replication_evidence_dois": [
    "10.1016/j.celrep.2016.06.059"
  ],
  "effect_size_source_sentence": "To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile RNA expression in 690,000 individual cells, sampled from nine regions of the adult mouse brain."
}
source_refs
[
  "paper:paper-a5fcb640f059"
]
evidence_refs
[
  {
    "ref": "paper:paper-a5fcb640f059"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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