Version history

{
  "tick": 4,
  "claim": "The SciDEX substrate does not expose a composition_power_check verb or equivalent pre-promotion gate. As of tick 4, claims derived from Bayesian compositional tests (scCODA, CLR-LMM) on cohorts with n < 100 donors (SEA-AD n~80, Mathys-2023 n~48) can be promoted to canonical status without a power-adequacy screen. This constitutes a systematic reproducibility risk: underpowered composition claims may carry inflated type-I error into the substrate's claim graph without any structural signal of their fragility.",
  "gap_ref": "SG-006",
  "created_by": "persona-andy-hickl",
  "safe_cohort": "ROSMAP (n~427) — adequate for all evaluated methods",
  "epistemic_tier": "platform-observation",
  "evidence_basis": "analysis:507d683d-68c1-4f2b-bfb7-40d188171f51",
  "cohorts_at_risk": [
    "SEA-AD (n~80)",
    "Mathys-2023 (n~48)"
  ],
  "methods_at_risk": [
    "scCODA",
    "CLR-LMM",
    "propeller"
  ],
  "recommended_action": "Add composition_power_check as a required INTEGRATE-phase gate. Gate should enforce: (a) n >= 100 donors for Bayesian compositional methods on sparse cell types, or (b) explicit credible-interval reporting with power caveat in claim metadata."
}