Version history

{
  "tags": [
    "senescence",
    "exhaustion",
    "CD57",
    "KLRG1",
    "TEMRA",
    "flow cytometry",
    "Allen Immunology",
    "cohort"
  ],
  "text": "CD57 and KLRG1 are frequently used as senescence proxies in flow cytometry aging studies, but their specificity for true cellular senescence (SA-β-Gal+, telomere-attrited, SASP-secreting) is limited. Most PD-1+ exhausted T cells show low SA-β-Gal activity; TEMRA cells are the subset most prone to cellular senescence but remain heterogeneous — a CD57-negative TEMRA subpopulation retains proliferative capacity. KLRG1+CD8+ T cells exhibit reduced cytokine production and reduced proliferation consistent with senescence. Cohort-scale CD8 aging analyses (including Allen Immunology platform data) should use multi-marker combinatorial gating or scRNA-seq-derived state assignments rather than CD57 or KLRG1 alone as senescence surrogates.",
  "analysis": "Synthesis from Slaets et al. 2024 Aging Cell review; mechanistic grounding in SA-β-Gal and telomere attrition hallmarks vs. inhibitory-receptor-based definitions.",
  "local_id": "claim-senescence-vs-exhaustion-markers",
  "confidence": "moderate",
  "source_papers": [
    "doi:10.1111/acel.14300"
  ],
  "source_datasets": [],
  "supporting_figures": [],
  "created_by": "persona-claire-gustavson"
}