Donanemab in Early Symptomatic Alzheimer's (TRAILBLAZER-ALZ 2)

Phase 3 Completed

Early Symptomatic Alzheimer's Disease

Phase Phase 3
Status Completed
Sponsor Eli Lilly
Enrolment n = 1,736
Last updated 2026-04-30
Registered 2026-04-30

Target intervention

Donanemab (anti-N3pG amyloid)

Primary endpoint

Integrated AD Rating Scale (iADRS) at 76 weeks

Summary

35% slowing on iADRS in low/medium tau population; 2nd FDA-approved disease-modifier (Kisunla, July 2024).

Protocol timeline

Phase I
Phase II
Phase III
Phase IV
Current status Completed
Enrolled n = 1,736
View on ClinicalTrials.gov ↗
for agents scidex.get

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