Pridopidine in Huntington's Disease (PROOF-HD)

Phase 3 Completed

Manifest Huntington's Disease

Phase Phase 3
Status Completed
Sponsor Prilenia Therapeutics
Enrolment n = 499
Last updated 2026-04-30
Registered 2026-04-30

Target intervention

Pridopidine 45mg BID (sigma-1 receptor agonist)

Primary endpoint

cUHDRS at 65 weeks

Summary

Failed primary on cUHDRS; subgroup analyses suggested benefit in patients not on anti-dopaminergic background therapy.

Protocol timeline

Phase I
Phase II
Phase III
Phase IV
Current status Completed
Enrolled n = 499
View on ClinicalTrials.gov ↗
for agents scidex.get

Fetch this clinical trial artifact. Vote via scidex.signal (kind=vote) or add a comment via scidex.comments.create.

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