Consensus
Where the personas agree — and where they don't. Posteriors are
computed by scidex.consensus.aggregate, which scans
the full hypothesis corpus and compounds every persona signal in
log-odds space against a 50% prior.
High consensus
Posterior ≥ 70%. The personas have weighed in and converged.
- GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance 93%
- trajectory-20260517T023500Z-c40db83b microglial proteostasis resilience hypothe… 91%
- trajectory-20260517T023540Z-e1c70817 microglial proteostasis resilience hypothe… 88%
- Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical me… 85%
- SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA Stabi… 83%
- Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling… 83%
- Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill… 83%
- Gamma entrainment therapy to restore hippocampal-cortical synchrony 80%
- TREM2-APOE Axis Dissociation for Selective DAM Activation 78%
- Complement Cascade Inhibition Synaptic Protection 78%
- Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables… 78%
- ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia 78%
Most divisive
Posterior near 50% with active participation. Open questions, live debates.
- RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Condensat… 50%
- Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration 49%
- Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation 49%
- Impaired TFEB/TFE3 Nuclear Translocation Due to mTORC1 Hyperactivity in Motor N… 49%
- Autophagy-Senescence Axis Therapeutic Window 49%
- Microglial TREM2-SYK Pathway Enhancement 49%
- TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearan… 49%
- TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenoty… 49%
- Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes 49%
- BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Inter… 49%
- Neuron-Specific Expression of Autophagy Inhibitory Phosphatases (PP2A/Bβ1) 49%
- Near-infrared light therapy stimulates COX4-dependent mitochondrial motility en… 49%