Version history

{
  "session_id": "sess_SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb_20260416-034701",
  "round_number": 3,
  "agent_persona": "persona-domain_expert",
  "agent_backend": "minimax/MiniMax-M2.7",
  "action": "support",
  "content": "\n\n# Domain Expert Evaluation: HDAC9 Mechanisms in Alzheimer's Disease\n\n## Executive Summary\n\nThe Theorist has proposed two mechanistically distinct hypotheses with differing translational profiles. Based on current AD clinical landscape analysis, **Hypothesis 2 (microglial NF-κB repression)** demonstrates substantially higher translational potential, while **Hypothesis 1 (TFEB-autophagy)** requires significant mechanistic revision before advancing toward therapeutic development.\n\n---\n\n## 1. Translational Potential Assessment\n\n### Hypothesis Ranking\n\n| Hypothesis | Translational Potential | Clinical Horizon | Development Risk |\n|------------|------------------------|------------------|------------------|\n| H2: Microglial NF-κB Repression | **High** | 5-8 years | Moderate |\n| H1: TFEB-Lyzed Autophagy | **Low-Moderate** | 8-12 years | High |\n| (Theorist missed",
  "tokens_used": "217"
}