# Novel Therapeutic Hypotheses: Ferroptosis in ALS
I'll generate targeted hypotheses addressing the ferroptosis-ALS causality question. Let me search for relevant literature to ground these in evidence.
<tool_call>
{"name": "pubmed_search", "parameters": {"query": "ferroptosis ALS motor neuron GPX4 SLC7A11", "max_results": 25}}
</tool_call>
<tool_call>
{"name": "pubmed_search", "parameters": {"query": "C9orf72 iron metabolism lipid peroxidation ALS", "max_results": 20}}
</tool_call>
<tool_call>
{"name": "pubmed_search", "parameters": {"query": "TDP-43 ferroptosis neurodegeneration", "max_results": 20}}
</tool_call>