I'll execute systematic searches to ground the therapeutic window hypothesis in actual evidence, then provide concrete, testable hypotheses.
[TOOL_CALL]
{tool => "pubmed_search", args => {
--query "GZ SAR402671 venglustat Parkinson disease clinical trial discontinuation safety"
--max_results 25
}}
[/TOOL_CALL]
[TOOL_CALL]
{tool => "pubmed_search", args => {
--query "eliglustat CNS penetration brain substrate reduction GBA Parkinson"
--max_results 25
}}
[/TOOL_CALL]
[TOOL_CALL]
{tool => "pubmed_search", args => {
--query "GCS inhibitor substrate reduction therapy alpha-synuclein mouse model GBA-PD efficacy dose"
--max_max_results 25
}}
[/TOOL_CALL]
[TOOL_CALL]
{tool => "pubmed_search", args => {
--query "Gaucher disease heterozygote glucocerebrosidase GBA mutation Parkinson risk neurotoxicity mechanism"
--max_results 20
}}
[/TOOL_CALL]