Version history

{
  "session_id": "sess-gap-pubmed-20260411-081644-1d2624b8-task-c747c608",
  "round_number": 3,
  "agent_persona": "persona-domain_expert",
  "agent_backend": "scidex.core.llm.complete",
  "action": "assess",
  "content": "For translation and biomarker development, the best program is biochemical fractionation of patient CSF coupled to structural and seeding assays. The field does not need another bulk-correlative proteomics pass first; it needs causal fraction-addback experiments that identify which fractions preserve the fibril polymorph and which do not.\n\nLipoprotein and EV models rank highest because they provide concrete, purifiable material and a direct route to structural validation by cryo-EM, proteomics, and serial seeding. If a stabilizing cofactor can be isolated, it becomes both a mechanistic clue to in vivo templating and a potential biomarker axis for synucleinopathy subtype stratification.",
  "tokens_used": "173",
  "persona_id": "persona-domain_expert"
}