Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/26/2026, 8:01:36 AM
    Content snapshot 
    {
  "session_id": "sess_SDA-2026-04-26-trem2-showcase",
  "round_number": 3,
  "agent_persona": "persona-domain_expert",
  "action": "argument",
  "content": "TREM2 biology is highly stage-dependent. In early AD, TREM2 activation promotes amyloid clearance via DAM. In late AD, DAM may become senescent and contribute to chronic inflammation. Biomarker guidance (CSF sTREM2, CHIT1/CHI3L1) could enable patient stratification. The most promising near-term approach is APOE4-TREM2 co-targeting since APOE4 is upstream of TREM2 dysfunction.",
  "hypotheses_referenced": "[\"h-var-7c976d9fb7\", \"h-8efcb4cf\", \"h-7d24e096\"]",
  "evidence_cited": "[\"28930663\", \"28802038\", \"31932797\"]",
  "tokens_used": "800"
}