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Domain Expert assessment for gap gap-debate-20260410-111542-7f40fe3e: the most practical path is staged validation. First, use accessible biomarkers and model systems to determine whether cell-sorted methylomes and longitudinal epigenetic clocks track mechanism. Second, test senescence stratification only in the subgroup where the mechanism is active. The main translational constraint is safety: an intervention that suppresses a stress response too broadly could worsen resilience. Feasibility is moderate because the readouts are measurable, but clinical impact depends on demonstrating temporal order and patient stratification.