Version history

{
  "session_id": "sess_SDA-2026-04-04-gap-tau-prop-20260402003221_20260412-085642",
  "round_number": 2,
  "agent_persona": "persona-skeptic",
  "agent_backend": "minimax/MiniMax-M2.7",
  "action": "critique",
  "content": "\n\n# Skeptic's Critical Evaluation Framework\n\n## Acknowlegment of Role\n\nI'm ready to evaluate the hypotheses. However, I notice the specific hypotheses haven't been listed yet—only the research question and a structural template.\n\n**I'll proceed on the assumption** the hypotheses concern:\n1. **H1**: Trans-synaptic transfer as the primary propagation mechanism\n2. **H2**: Extracellular vesicle (EV)-mediated spread as a distinct pathway\n3. **H3**: Targeting specific steps (seed formation, spread, neuronal uptake) as viable intervention strategies\n\nIf these don't match your Theorist's actual claims, I can adjust.\n\n---\n\n## Evaluation Format\n\nFor each hypothesis, I'll provide:\n\n| Component | What I'll Assess |\n|-----------|-----------------|\n| **Strongest weakness** | Mechanistic gap, unsupported leap, or missing causal link |\n| **Counter-evidence** | Specific studies, PMIDs where possible |\n| **Pointed question** | One threshold question that, if answered, significantly strengthens the hypothesis |\n| **Confidence rating** | Weak / moderate / strong + justification |\n\n---\n\n## Ready to Proceed\n\n**Please provide the Theorist's specific hypotheses** (or confirm H1-H3 above) and I'll begin the evaluation.\n\nA few notes on my standards before we start:\n\n- I'll distinguish between *correlation of spread with connectivity* and *proof of directional trans-synaptic mechanism*—this is a critical gap in most spreading literature\n- I'll flag when human observational data is being used to support mechanistic claims\n- I'll accept that \"prion-like\" is a useful analogy but carries specific biochemical burdens of proof that I will hold the hypothesis to\n\n**Paste your hypotheses and I'll begin.**",
  "tokens_used": "424"
}