debate_session
+ New debate_sessionAll debate_sessions
- Test
SDA-2026-04-29-gap-test-20260425-224949
- Second debate: Microglial TREM2-SYK Pathway Enhancement
SDA-2026-04-03-gap-seaad-v4-20260402065846
- Second debate: Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector
["theorist", "skeptic", "domain_expert", "synthesizer"]
- Structured Research Brief: Tau dysfunction destabilizes labile pool
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- Structured Research Brief: Tau/MAP6 ratio as a master switch for microtubule dynamics plasticity
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- Structured Research Brief: APOE4-Specific Proteolytic Fragment Inhibition Therapy
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- Structured Research Brief: GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro1 Degradation, Creating a Pink1-Parkin M
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- Structured Research Brief: SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents TorsinA-Mediated LAMP2A Turnover, Stabilizing Toxic Conformation
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- Structured Research Brief: PD-Associated GWAS Variants in CTSO and CTSF Genes Create a Synthetic Lethal Interaction with GBA1 Mutation Carriers via
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- Structured Research Brief: GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic Neurons that is Defective Due to LAMP2A Insuffi
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- Structured Research Brief: Exosomal SNCA Propagation from Lysosome-Compromised Neurons Contains a Distinct Lysosomal Proteome Signature that Primes
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- Structured Research Brief: LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergic Neurons Create Selective Vulnerability to SNCA-Mediated CM
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- Structured Research Brief: Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate
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- Structured Research Brief: PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αSyn) and AD (tau/Abeta) Pathology
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- Structured Research Brief: Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanism for α-Synuclein (PD) and Tau (AD) Trans-synaptic Propagati
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- Structured Research Brief: Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector
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- Structured Research Brief: Lysosomal Cathepsin-Dependent Tau Clearance
structured_research_brief
- Structured Research Brief: METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Sequestration Capacity
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- Structured research brief (iter2): ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 to Protect Synaptic Membranes from Aβ-Induced Rigidificatio
SDA-2026-04-16-frontier-lipidomics-dcdbc360
- Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD Spectrum
SDA-2026-04-13-gap-20260410-172514
- Structured research brief: Dual-Receptor Antibody Shuttling
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- Structured research brief: GLE1-Mediated mRNA Export Defect Creates Translation-Competent mRNA Starvation in ALS Motor Neuron Axons
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- Structured research brief: SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA Stability Loss in ALS Motor Neurons
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- Structured research brief: RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Condensates Toward Pathological Aggregation in ALS
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- Structured research brief: ATM Kinase Hyperactivation Triggers DNA Damage Response Overflow and p53-Dependent Motor Neuron Apoptosis in ALS
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