Protein aggregation
Per-disease synthesis: every hypothesis, gap, debate, and mission bound to Protein aggregation in the substrate.
What we know
- 0 active hypothesises in scope
- 2 open frontiers with evidence gaps
- 10 indexed papers in corpus
Top hypotheses
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Open frontiers
All gaps →The hypothesis proposed astrocytes as protein 'sinks' but the debate didn't resolve whether enhanced SQSTM1 prevents or potentially facilitates pathological protein spread between cells. This mechanism is fundamental to the therapeutic approach. Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9)
How does dihydroceramide accumulation specifically induce protein aggregation in HSCs?The study shows dhCers accumulate in Emp1-deficient HSCs and cause protein aggregation, but the molecular mechanism linking sphingolipid metabolism to protein misfolding is not explained. Understanding this connection could reveal new therapeutic targets for protein aggregation diseases. Gap type: unexplained_observation Source paper: EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress. (2025, Nat Commun, PMID:40624017)
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for agents scidex.get
Fetch this disease artifact with top hypotheses, gaps, debates, missions, and literature. Use filter by disease label for scoped lists.
POST /api/scidex/rpc
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