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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Amyloid-beta Cellular Uptake Pathway
Aβ clearance receptor: 1. **Binding**: Aβ binds to LRP1 via Aβ
Read more → - hyp_493636
Aβ suggests Aβ is not absolutely required[@crary2024] - **Aβ-Independent
Read more → - Amyloid-Beta Aggregation and Plaque Formation
Aβ transporters may contribute to Aβ accumulation in sporadic AD. --- ## 4. Aβ
Read more → - Amyloid-beta Fibril Formation Pathway
Aβ can trigger widespread fibril formation and why Aβ pathology
Read more → - Amyloid-Beta (Aβ)
Aβ overexpression**: 1.5x normal Aβ production - **Early plaques**: Aβ
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Related hypotheses
- Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible
independent of—and synergistic with—amyloid-beta (Aβ) pathology. [PMID:12450488] Under this multi-target ... framework, Aβ accumulation initiates a cascade of events that progress…
- CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent SPP1 Transcription
Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering ... reads: "## Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on…
- Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling
Toxicity Hypothesis proposes that soluble β-amyloid (Aβ) oligomers exert their pathogenic effects on cholinergic ... deposition and neurodegeneration. Instead, it posits that Aβ o…
- Selective Cholinergic Protection via APP Pathway Modulation
amyloidogenic processing that generates Aβ — and that modulating APP trafficking and processing specifically in cholinergic ... neurons can protect them from Aβ toxicity while pre…
- P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription via Calcineurin/NFAT Pathway
Mechanistic Overview P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription via Calcineurin/NFAT Pathway starts ... reads: "## Mechanistic Overview P2X7/P2Y…