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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Enteric Neurons in Alzheimer's Disease
amyloid plaques, and tau pathology in the enteric nervous system
Read more → - Amyloid Precursor Protein (APP)
amyloid plaques](/mechanisms/amyloid-pathology) but no dementia ( [amyloid plaques](/mechanisms/amyloid-pathology) without
Read more → - Aducanumab (Aduhelm)
amyloid plaques deposited in the brain parenchyma - **Amyloid plaques**: Dense
Read more → - Amyloid plaque and neurofibrillary tangle deposition is an essential component for accurate modeling...
Amyloid Plaques Amyloid plaques are extracellular aggregates of amyloid-beta
Read more → - Pathologic Synergy Occurring in the Amygdala Between Amyloid Plaques and Tau/NFT May Facilitate the Transition from PART to AD
Amyloid Plaques and Tau/NFT May Facilitate the Transition from Primary
Read more →
Graph neighborhood (25 nodes · 48 edges)
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Related hypotheses
- Microglial TREM2-SYK Pathway Enhancement
anti-TREM2 antibodies reduce amyloid plaque burden in 5XFAD mice (MAbs 2022, PMID ... hippocampus, temporal cortex, and around amyloid plaques. Disease-associated microglia (DAM) …
- Cell-Type Specific TREM2 Upregulation in DAM Microglia
microglia cluster around dense-core amyloid plaques, forming a physical barrier that compacts the plaque ... GENES --> DAM2 DAM2 -->|"plaque barrier"| AB["Amyloid Plaques"] DAM2…
- [Archived Hypothesis]
immunoreceptor that governs microglial responses to amyloid plaques and neuroinflammatory stimuli. The molecular mechanism involves ... Consequently, microglia exhibit reduced clu…
- TREM2-APOE Axis Dissociation for Selective DAM Activation
required for APOE deposition at amyloid plaques and that this APOE accumulation is not merely ... alleles exhibit progressive APOE accumulation at amyloid plaques and APOE-depende…
- ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling
hippocampus, temporal cortex, and around amyloid plaques. Disease-associated microglia (DAM) are defined by TREM2 ... hippocampus, temporal cortex, and around amyloid plaques; BAM…