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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Hepsin Protein
process [Amyloid Precursor Protein (APP)][@hepsin_app_processing][@app_cleavage
Read more → - APP Processing and Amyloid-Beta Production
APP Processing and Amyloid-Beta Production ## Introduction Add App Processing
Read more → - APP — Amyloid Precursor Protein
APP Processing Pathways APP undergoes proteolytic processing through two mutually
Read more → - APP Protein
process influences APP stability, trafficking, and proteolytic processing. ## Processing Pathways
Read more → - Soluble Amyloid Precursor Protein Beta (sAPPβ)
APP Processing Pathway - APP - APP Gene - Amyloid precursor protein encoding
Read more →
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Related hypotheses
- Selective Cholinergic Protection via APP Pathway Modulation
that promote non-amyloidogenic processing) shifts APP processing toward sAPPα, reduces Aβ production, and provides ... animal models by promoting non-amyloidogenic APP processing …
- Palmitoylation-Targeted BACE1 Trafficking Disruptors
differential subcellular distribution of APP processing machinery. While APP is present throughout cellular membranes ... secretase ADAM10, which mediates non-amyloidogenic APP pr…
- Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology
regulatory control of amyloid precursor protein (APP) processing proposes a self-amplifying feedforward loop wherein ... Mechanism of Action ### Cholinergic Modulation of APP Proc…
- SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction
incompletely understood. The amyloid precursor protein (APP) processing pathway, particularly the activities of beta-secretase ... sphingolipids that serve as platforms for APP pr…
- CYP46A1 Small Molecule Activator Therapy
This approach employs pharmacological activation