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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CHAT Gene
CHAT["CHAT"] Pterostilbene["Pterostilbene"] -->|"upregulates"| CHAT["CHAT"] ALZHEIMER["ALZHEIMER"] -->|"associated
Read more → - Dorsal Motor Nucleus of the Vagus
CHAT["CHAT"] -->|"associated with"| Dementia["Dementia"] CHAT["CHAT"] -->|"regulates"| NGF["NGF"] CHAT
Read more → - Validated Hypothesis: Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible
CHAT (Choline O-Acetyltransferase):** - CHAT synthesizes the neurotransmitter acetylcholine and is expressed
Read more → - CHAT Protein
CHAT Protein | Property | Value | |----------|-------| | **Protein Name** | Choline Acetyltransferase | | **Gene** | CHAT
Read more → - Choline Acetyltransferase (ChAT) Neurons
ChAT) Neurons ## Overview Choline acetyltransferase (ChAT) neurons are a distinct
Read more →
Graph neighborhood (30 nodes · 72 edges)
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Related hypotheses
- Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible
Cholinergic Neuron Toxicity"] B --> C["Reduced ChAT Expression"] C --> D["Decreased Acetylcholine Release ... synaptic vesicle trafficking independently of Aβ production. **CHAT …
- Sensory-Motor Circuit Cross-Modal Compensation
Compensation starts from the claim that modulating CHAT within the disease context of neuroscience ... cholinergic system, particularly neurons expressing choline acetyltransferas…
- Cholinergic Basal Forebrain-Hippocampal Circuit Protection
through the rate-limiting enzyme choline acetyltransferase (ChAT). The disrupted microtubule network impairs anterograde transport ... ChAT, vesicular acetylcholine transporter (V…
- NAMPT-Centered NAD+ Restoration to Reverse Basal Forebrain Cholinergic Neuron Metabolic Failure
acetylcholine synthesis and axonal transport. Choline acetyltransferase (ChAT) requires acetyl-CoA derived from mitochondrial pyruvate ... knockout models remain limited, related …
- Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology
axonal transport including that of choline acetyltransferase (ChAT). Aβ additionally induces astrogliosis and microglial activation ... autopsy studies demonstrate inverse correla…