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SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Cerebral Ischemia Pathway in Neurodegeneration
Ischemia in Neurodegeneration ## Overview Cerebral ischemia represents a critical pathogenic
Read more → - stroke-neurodegeneration-pathway
ischemia leads to excitotoxicity | [@moskowitz2022] | **NMDA Receptors** | Calcium-permeable channels
Read more → - Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
ischemia and more severe oxidative stress from whole-body ischemia
Read more → - Validated Hypothesis: Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic and Vasogenic Edema After Cardiac Arrest
Ischemia-reperfusion generates massive oxidative stress, depleting glutathione reserves and overwhelming
Read more → - Adenosine A2B Receptor Neurons
Ischemia A2B receptors are particularly important in cerebral ischemia: **Ischemic
Read more →
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Related hypotheses
- SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
arrest initiates a devastating cascade of cerebral ischemia and reperfusion injury that ranks among ... ischemic stroke, with global rather than focal ischemia and more severe oxi…
- Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic and Vasogenic Edema After Cardiac Arrest
converging pathways relevant to cardiac arrest pathophysiology. Ischemia-reperfusion generates massive oxidative stress, depleting glutathione ... edema formation, which in turn p…
- SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation in Post-CA Brain
metabolism, redox homeostasis, and neuronal survival after ischemia-reperfusion injury. **Mechanism of Action** SIRT1 ... neurons and cerebral endothelial cells recovering from is…
- Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection
during and after cardiac arrest-induced cerebral ischemia-reperfusion injury. This master transcriptional regulator orchestrates ... vulnerable to matrix metalloproteinase-mediate…
- Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron-Ferroptosis-Edema Cascade Post-Cardiac Arrest
injury cascade represents a complex interplay of ischemia-reperfusion injury, iron dysregulation, and ferroptotic cell ... iron available for catalyzing harmful reactions. However…