No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Astrocyte-Neuron Metabolic Coupling Pathway
lactate by lactate dehydrogenase 5 (LDH5), favoring lactate production 4. **Lactate
Read more → - Lactate Lactylation in Neurodegeneration
lactate["lactate"] SIRT1["SIRT1"] -->|"modulates"| lactate["lactate"] ischemia_reperfusion_injury
Read more → - Oligodendrocyte-Neuron Metabolic Support Pathway in Neurodegeneration
Lactate Shuttle Mechanism ### Historical Context and Discovery The lactate shuttle
Read more → - Metabolic Coupling and the Energy Substrate of Computation
lactate flux impairs learning or plasticity, and exogenous L-lactate
Read more → - Validated Hypothesis: Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
lactate through glycolysis. This lactate is then exported via monocarboxylate
Read more →
Graph neighborhood (30 nodes · 59 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
GLUT1 transporters and convert it to lactate through glycolysis, exporting it via MCT1 (SLC16A1 ... neighboring motor neurons, which preferentially utilize lactate for ATP product…
- Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics
Mechanistic Overview Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics starts from the claim that ... hypothesis centers on enhancing the astrocyte-neuron lactate…
- Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction
Mechanistic Overview Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction starts from ... original description reads: "**Parvalbumin Inte…
- Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling
Molecular Mechanism and Rationale The astrocyte-neuron lactate shuttle (ANLS) is a fundamental metabolic coupling ... mechanism where astrocytes convert glucose to lactate via aer…
- Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker
Mechanistic Overview Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker starts from the claim that ... original description reads: "## Mechanistic Overview Dyn…