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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Lysosomal Dysfunction in Neurodegeneration
lysosomal_dysfunction["lysosomal dysfunction"] TBK1["TBK1"] -->|"prevents"| lysosomal_dysfunction["lysosomal
Read more → - Lysosomal Dysfunction in Progressive Supranuclear Palsy
lysosomal_dysfunction["lysosomal dysfunction"] TBK1["TBK1"] -->|"prevents"| lysosomal_dysfunction["lysosomal
Read more → - Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD
Dysfunction"] TBK1["TBK1 Mutations"] end subgraph Lysosomal["Lysosomal Dysfunction"] CatD
Read more → - Lysosomal Storage Diseases
Lysosomal_Dysfunction["Lysosomal Dysfunction"] -->|"causes"| Lysosomal_Storage_Diseases["Lysosomal Storage
Read more → - Autophagy-Lysosomal Dysfunction Neurons
Lysosomal Dysfunction in Neurodegeneration Autophagy-Lysosomal Dysfunction Neurons Protein/Gene Function
Read more →
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Related hypotheses
- Lysosomal Enzyme Trafficking Correction
worm M6PR ortholog) exhibited profound lysosomal dysfunction and shortened lifespans. Pharmacological chaperone treatment extended mean ... trafficking defects, prophylactic chape…
- TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis
this hypothesis is the connection between lysosomal dysfunction and hypoxic signaling through the TFEB ... 1alpha-mediated neuroprotection is needed. 2. **Lysosomal dysfunction an…
- TREM2-ASM Crosstalk in Microglial Lysosomal Senescence
months of age, accompanied by enlarged, dysfunctional lysosomes and impaired autophagy flux. Pharmacological ASM inhibition ... pathway label is `TREM2-sphingomyelin-ceramide-lyso…
- The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
cellular pathology, including protein aggregation, mitochondrial dysfunction, and lysosomal impairment, suggesting a convergent mechanism ... cellular stress, including energy dep…
- APOE4 preferentially signals through LRP1 over LDLR, altering endosomal cholesterol trafficking and causing lysosomal cholesterol sequestration that drives lysosomal dysfunction and inflammation
compared to 18% for APOE3 controls. Lysosomal dysfunction manifests as enlarged LAMP1-positive structures ... mechanistic pathway from receptor binding through lysosomal dysfuncti…