No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Prionoid Propagation of Protein Aggregates in Neurodegeneration
Lysosomal Exocytosis Damaged lysosomes can release their contents through lysosomal
Read more → - Mucolipin-1 (TRPML1) Protein
lysosomal exocytosis, autophagosome-lysosome fusion, [TFEB](/genes/tfeb) nuclear translocation, lysosomal
Read more → - MCOLN1 — Mucolipin-1 (TRPML1)
lysosomal exocytosis induced by lysosomal Ca2+ channel agonists is blocked
Read more → - VAMP7 Gene
Lysosomal exocytosis** — VAMP7 mediates Ca²⁺-triggered lysosomal fusion with the plasma
Read more → - VAMP8 — Vesicle Associated Membrane Protein 8
Lysosomal exocytosis**: VAMP8 facilitates the release of lysosomal contents during
Read more →
Graph neighborhood (2 nodes · 1 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons
nuclear translocation, and transcriptional upregulation of lysosomal exocytosis machinery (LAMP1, VAMP7, RAB7), enabling swollen aggregate ... PIKFYVE inhibition paradoxically act…
- C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by PIKFYVE Inhibition via Lysosomal Exocytosis Restoration
Rescued by PIKFYVE Inhibition via Lysosomal Exocytosis Restoration starts from the claim that modulating C9orf72/SMCR8/RAB7A/PIKFYVE ... Rescued by PIKFYVE Inhibition via Lysosoma…
- TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis
signaling. It regulates lysosomal exocytosis, autophagosome-lysosome fusion, and lysosomal biogenesis via calcineurin-TFEB signaling ... PIKFYVE inhibition activates MCOLN1-mediat…
- Sequential TRPML1 Activation Following Autophagy Priming
signaling. It regulates lysosomal exocytosis, autophagosome-lysosome fusion, and lysosomal biogenesis via calcineurin-TFEB signaling ... PIKFYVE inhibition activates MCOLN1-mediat…
- TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis
genes involved in lysosomal biogenesis, autophagy, lysosomal exocytosis, and membrane trafficking. When activated, TFEB translocates ... cellular degradation machinery or promote …