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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Caspase-3 (CASP3)
PARP Cleavage:** Excessive PARP cleavage depletes cellular energy reserves, accelerating
Read more → - casp3
cleavage: separates large and small subunits - Active enzyme: heterotetramer (p17/p11)₂ ### Substrate Specificity Activated caspase-3 cleaves over 600 known substrates: [@snigdha2016] - **DNA repair proteins**: PARP
Read more → - Caspase-7 Protein
PARP cleavage**: Excessive caspase-7 activation causes PARP cleavage, leading
Read more → - CASP7 Gene
PARP (Poly ADP-Ribose Polymerase)**: Cleavage inactivates PARP's DNA repair
Read more → - AIFM1 Gene
cleavage**: Ca²⁺-dependent calpains cleave AIF at residue 1025, releasing it from the inner membrane - **Nuclear translocation**: Cleaved AIF (tAIF, ~57 kDa) translocates to the nucleus in a PARP
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Related hypotheses
- PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation
Hypothesis 1. DDR markers including PARP-1 cleavage are significantly upregulated in lumbar motor neurons ... PARP1 upregulation may be protective; PARP-1 cleavage is associated w…
- DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop
damage induces TDP-43 cleavage and mislocalization. [PMID:29435550]. 3. APOE4 brains show elevated ... does not explain initiation. Identifier N/A. 3. PARP inhibitors have failed …
- Metabolic Reprogramming to Reverse Senescence
while also sustaining DNA repair capacity through PARP activation—a relevant consideration given the accumulated ... enzyme's catalytic mechanism involves NAD+ cleavage at the nic…
- R-Loop Resolution Enhancement Therapy
with the transcription termination machinery, including the cleavage and polyadenylation specificity factor (CPSF) complex ... targeting DNA damage in neurodegeneration, such as P…