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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- TREM2 Microglial Signaling Pathway in Neurodegeneration
TREM2 Microglial Signaling Pathway in Neurodegeneration ## Overview TREM2 (Triggering Receptor
Read more → - TREM2 in Frontotemporal Dementia
TREM2 in FTD ### TREM2 Variants and FTD Risk While TREM2
Read more → - TREM2 Signaling in Neurodegeneration
TREM2["TREM2 Receptor"] TREM2 -->|"associates with"| DAP12["DAP12 / TYROBP ITAM
Read more → - TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain
TREM2 mRNA | Repression | | miR-155 | TREM2 | Negative regulation | | miR-124 | TREM2
Read more → - TREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity
TREM2 in the disease process[@catala2024]. Importantly, the level of TREM2
Read more →
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Related hypotheses
- APOE-TREM2 Interaction Modulation
Mechanistic Overview APOE-TREM2 Interaction Modulation starts from the claim that modulating TREM2 within ... description reads: "The interaction between APOE and TREM2 on microgl…
- Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's disease
Mechanistic Overview Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's disease ... starts from the claim that modulating TREM2 within th…
- TREM2-APOE Axis Dissociation for Selective DAM Activation
Mechanistic Overview TREM2-APOE Axis Dissociation for Selective DAM Activation starts from the claim that ... modulating TREM2-APOE axis within the disease context of neurodegener…
- TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance
Mechanistic Overview TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance starts from the claim ... that modulating TREM2 within the disease con…
- TREM2-mediated microglial tau clearance enhancement
Mechanistic Overview TREM2-mediated microglial tau clearance enhancement starts from the claim that modulating TREM2 ... Triggering receptor expressed on myeloid cells 2 (TREM2) h…