amyloidogenic_APP_processing

Wiki pages (5)

SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.

• AP2M1 Gene

  APP Processing ### Amyloidogenic vs. Non-Amloidogenic Pathways AP2M1 critically influences

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• SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal Chain

  APP ### Amyloidogenic Processing Cascade The amyloidogenic processing of [APP](/genes/app

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• ADAM10 — A Disintegrin And Metalloproteinase Domain 10

  Amyloidogenic APP Processing ADAM10 cleaves APP between residues Lys⁶⁸⁷ and Leu⁶⁸⁸ (within

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• KIF13A Protein

  APP undergoes amyloidogenic (β-secretase cleavage) or non-amyloidogenic (α-secretase cleavage) processing

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• APP-BACE1-Fe65 Complex

  processing pathways: the amyloidogenic pathway, which produces Aβ peptides via sequential BACE1 and gamma-secretase cleavage, and the non-amyloidogenic pathway, which cleaves APP

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Graph neighborhood (2 nodes · 2 edges)

Related hypotheses

• M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute

  matched controls; CHRM1 stimulation promotes non-amyloidogenic APP processing via ADAM10; M1 agonist (cevenamer) showed ... matched controls; CHRM1 stimulation promotes non-amyloi…

• Palmitoylation-Targeted BACE1 Trafficking Disruptors

  secretase ADAM10, which mediates non-amyloidogenic APP processing, predominantly localizes to non-raft membrane domains ... plasticity, myelin maintenance) while selectively dimin…

• CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalling in Neurodegeneration

  This hypothesis proposes that CYP46A1

• CYP46A1 Overexpression Gene Therapy

  that activates LXRs and promotes non-amyloidogenic APP processing via α-secretase upregulation, creating

• Blood-Brain Barrier SPM Shuttle System

  beta-42 secretion by promoting non-amyloidogenic APP processing. Also induces anti-apoptotic