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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- ABCA1 - ATP-Binding Cassette Transporter A1
efflux Cholesterol_Efflux["Cholesterol Efflux"] ABCA1 -->|"mediates"| Cholesterol_Efflux cholesterol
Read more → - LXR Protein (Liver X Receptor)
cholesterol efflux to ApoA1 - Activate ABCG1: Mediates cholesterol efflux to HDL - Activate
Read more → - ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal Chain
cholesterol efflux**: Accumulation of cholesterol in astrocytes/microglia 3. **Defective Aβ clearance
Read more → - Validated Hypothesis: miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
cholesterol efflux when cellular cholesterol levels are adequate. However, in the context
Read more → - ABCG1 Gene
Cholesterol Efflux**: ABCG1 expressed on neurons facilitates cholesterol efflux to astrocyte
Read more →
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Related hypotheses
- APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intracellular lipid droplet accumulation and secondary neuronal cholesterol deficiency
Mechanistic Overview APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intracellular lipid droplet ... lipid-poor APOE, while ABCG1 enhanc…
- miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
transcriptional suppression of ABCA1, the primary cholesterol efflux transporter responsible for lipidating nascent APOE particles ... metabolic brake, preventing excessive choles…
- H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astrocyte Senescence
compared to APOE3, fundamentally disrupting cholesterol efflux mechanisms. At the cellular level, astrocytes expressing APOE4 ... ABCA1, the rate-limiting transporter for cholest…
- HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention
promoter. LXR activation increases ABCA1-mediated cholesterol efflux, enhancing apoE lipidation and promoting the formation ... ABCA1, enhancing ATP hydrolysis and cholesterol eff…
- Membrane Cholesterol Gradient Modulators
domains**: ApoE-derived sequences that promote cholesterol efflux, conjugated to synaptic targeting motifs ... molecules that allosterically activate ABCA1-mediated cholesterol ef…