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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- NPC2 — NPC Intracellular Cholesterol Transporter 2
Cholesterol esterification**: ACAT-mediated cholesterol esterification in the ER - **LDL receptor
Read more → - Niemann-Pick Disease Type C (NPC)
cholesterol to the ER for esterification or to the plasma
Read more → - Cerebral Cholesterol Metabolism
cholesterol esterification, promoting free cholesterol availability and ABCA1-mediated efflux
Read more → - APOE4 Lipid Metabolism Optimization
cholesterol esterification to increase available cholesterol for APOE lipidation[@bryleva2010
Read more → - DGAT1 — Diacylglycerol O-Acyltransferase 1
Cholesterol Esterification | Shares substrates (DAG) | | Ceramide Synthesis | Cross-talk with
Read more →
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Related hypotheses
- TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation
debris, amyloid plaques, and damaged membranes. ## Cholesterol Esterification as the Metabolic Bottleneck Under normal physiological ... foam cell models have established that cho…
- APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intracellular lipid droplet accumulation and secondary neuronal cholesterol deficiency
versus APOE3 brains, consistent with increased cholesterol esterification. Importantly, APOE levels in cerebrospinal fluid ... such as avasimibe derivatives could reduce cholester…
- Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's disease
involved in lipid uptake (LDLR, CD36), cholesterol esterification (ACAT1, SOAT1), and the LXR-ABCA1 axis
- APOE ε4 Drives Lipid Droplet Accumulation in a Unique Lipid-Associated Microglial Substate that Impairs Amyloid Phagocytosis
APOE ε4 promotes excessive cholesterol esterification and neutral lipid droplet accumulation in a discrete lipid