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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- GLUL — Glutamine Synthetase
Glutamate homeostasis** - Converts synaptic glutamate to glutamine - Prevents excitotoxic glutamate
Read more → - Excitotoxicity in Neurodegeneration
Glutamate Homeostasis Glutamate is the primary excitatory neurotransmitter in the central
Read more → - GLUD1 - Glutamate Dehydrogenase 1
Glutamate homeostasis**: Regulates extracellular glutamate levels - **GABA synthesis**: Provides glutamate
Read more → - Glutamate Excitotoxicity in Neurodegeneration
Glutamate Homeostasis Precise control of extracellular glutamate concentrations is critical
Read more → - ad-astrocyte-reactivity-companies
Glutamate homeostasis restoration** — correcting impaired glutamate transport and reducing excitotoxicity
Read more →
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Related hypotheses
- Heterogeneous astrocyte activation states differentially impact neuronal survival across AD progression
including complement-mediated synapse elimination, impaired glutamate homeostasis, blood-brain barrier (BBB) dysfunction, and loss ... neuroprotective function of healthy astrocyt…
- Cross-Cell Type Synaptic Rescue via Tripartite Synapse Restoration
encoded by SLC1A2) maintains synaptic glutamate homeostasis by rapidly clearing released neurotransmitter, preventing excitotoxicity while ... enhancement initiated first to estab…
- AQP4-Dependent Astrocyte Swelling Exacerbates Excitotoxic Neuronal Death via Dysfunction of the Glutamate-Gln Cycle
nexus between astrocyte volume regulation and glutamate homeostasis in the central nervous system. AQP4 ... include potential disruption of physiological glutamate signaling and w…
- Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutamate Toxicity
represents a critical component of cellular glutamate homeostasis and oxidative stress response in amyotrophic lateral ... exchange of extracellular cystine for intracellular glut…
- Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic enhancement and amyloid clearance from PV interneurons in Alzheimer's disease
glutamate transporters maintain optimal glutamate homeostasis necessary for proper interneuron function. **Preclinical Evidence** Extensive preclinical ... forebrain cholinergic n…