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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- ADAM10 — A Disintegrin And Metalloproteinase Domain 10
Non-Amyloidogenic APP Processing ADAM10 cleaves APP between residues Lys⁶⁸⁷ and Leu⁶⁸⁸ (within
Read more → - KIF13A Protein
APP undergoes amyloidogenic (β-secretase cleavage) or non-amyloidogenic (α-secretase cleavage) processing
Read more → - AP2M1 Gene
APP Processing ### Amyloidogenic vs. Non-Amloidogenic Pathways AP2M1 critically influences
Read more → - Cholinergic System Degeneration in Alzheimer's Disease
APP) processing through muscarinic receptor activation. M1 muscarinic receptor stimulation activates protein kinase C (PKC) and α-secretase, promoting the non-amyloidogenic
Read more → - Notch Signaling Pathway in Neurodegeneration
non-amyloidogenic processing of APP and Notch receptor cleavage: - ADAM10
Read more →
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Related hypotheses
- M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute
matched controls; CHRM1 stimulation promotes non-amyloidogenic APP processing via ADAM10; M1 agonist (cevenamer) showed ... matched controls; CHRM1 stimulation promotes non-amyloi…
- CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalling in Neurodegeneration
This hypothesis proposes that CYP46A1
- CYP46A1 Overexpression Gene Therapy
that activates LXRs and promotes non-amyloidogenic APP processing via α-secretase upregulation, creating
- Palmitoylation-Targeted BACE1 Trafficking Disruptors
secretase ADAM10, which mediates non-amyloidogenic APP processing, predominantly localizes to non-raft membrane domains
- Blood-Brain Barrier SPM Shuttle System
beta-42 secretion by promoting non-amyloidogenic APP processing. Also induces anti-apoptotic