No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- p75NTR Protein
Pro-apoptotic | | BDNF | p75NTR/TrkB | Pro-survival | | Pro-BDNF | p75NTR/Sortilin | Pro
Read more → - BCL2 Gene
Pro-apoptotic BCL-2 family member - [BAK1 Gene](/genes/bak1) - Pro
Read more → - BOK — BCL2 Family Ovarian Killer
pro-apoptotic BOK and anti-apoptotic proteins determines whether cells
Read more → - p75NTR Signaling Pathway
Pro-apoptotic"] N --> P["Pro-survival"] B --> Q["PI3K/Akt Pathway
Read more → - Intrinsic Apoptosis Pathway in Neurodegeneration
pro-apoptotic and anti-apoptotic signals is crucial for developing
Read more →
Graph neighborhood (30 nodes · 31 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- Metabolic Reprogramming Toward GAPDH Inhibition
redirecting cellular energy metabolism away from pro-apoptotic GAPDH nuclear translocation and toward autophagy-supporting ... activates demethylases that demethylate and activate…
- Apoptosis-Senescence Decision Point Intervention
deleterious effects. The hypothesis of enhancing pro-apoptotic signals specifically in pre-senescent cells through ... promotes apoptosis through transcriptional upregulation of p…
- Differential Calpain-Mediated Cleavage of Apoptotic vs. Autophagic Substrates
cathepsin release activates calpains which cleave pro-apoptotic proteins, but the cited evidence (PMID ... shows calpain-cleaved BID (tBID) remains pro-apoptotic and translocates …
- Autophagy-Senescence Axis Therapeutic Window
balance shifts toward pro-apoptotic BAX/BAK, contributing to neuronal loss. - **Datasets:** Allen Human Brain Atlas ... through PI3K-Akt signaling - BAX/BAK activation (pro-apopto…
- Oligodendrocyte Precursor Cell Senescence in White Matter Disease
balance shifts toward pro-apoptotic BAX/BAK, contributing to neuronal loss. - **Datasets:** Allen Human Brain Atlas ... through PI3K-Akt signaling - BAX/BAK activation (pro-apopto…