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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CERS2 Protein (Ceramide Synthase 2)
Sphingomyelin synthesis**: Ceramide is converted to sphingomyelin by sphingomyelin synthases
Read more → - SMPD1 Gene - Acid Sphingomyelinase
sphingomyelin synthesis - **Ceramide analogs**: Modulate ceramide-mediated signaling - **Gene therapy
Read more → - Sphingolipid Metabolism in Neurodegeneration
synthesis, salvage pathway, and sphingomyelin hydrolysis—ceramide acts as both
Read more → - Metabolomics in Neurodegeneration
sphingomyelin hydrolysis and de novo synthesis. [Cholesterol](/mechanisms/cholesterol-metabolism-neurodegeneration) homeostasis is disrupted
Read more → - Sphingolipid Metabolism in Neurodegeneration
synthesis** in the ER; (2) **sphingomyelin hydrolysis** by sphingomyelinases (acid
Read more →
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Related hypotheses
- SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction
neuronal cells, leading to increased sphingomyelin synthesis and accumulation within cellular membranes, particularly in endosomal ... potential therapeutic intervention point, as…
- Sphingomyelin Synthase Activators for Raft Remodeling
Activation*. SMS activation could increase sphingomyelin synthesis globally, potentially altering membrane properties in non-target
- APOE4-Selective Lipid Nanoemulsion Therapy
lipid raft remodeling effect of sphingomyelin synthesis enhancement would synergize with cholesterol delivery from nanoemulsions